Static Trial

STATIC is a study that is looking at people who have been diagnosed with Crohn’s Disease (CD) in the past, who are taking a specific type of medication known as an amino salicylate (5-ASA), but whose disease is not flaring (is in remission).

 

Why are we doing this study?

5-ASAs are one of the most commonly prescribed classes of drugs for Crohn’s Disease worldwide. Generally, they are considered to be safe and inexpensive, though rare but serious side effects can occur. In a review of clinical trials that tested whether 5-ASAs are effective for the management of CD, there is considerable uncertainty as to whether or not the treatment is of any benefit in maintaining remission for patients with CD.

This research study will aim to answer the question of whether 5-ASAs should be continued in subjects with CD who are in remission.

Static Logo

If you participate in this study your health will be monitored over five visits by a physician, in a two-year period. Half of all participants will be asked to stop taking their current dose and brand of 5-ASAs, the other half will continue to take their existing dose and brand of 5-ASA. Monitoring your health will consist of vital signs, collection of blood, urine, and stool, as well as answering questions regarding your visits to healthcare professionals, and your quality of life.

The study is being conducted at the NIHR Nottingham Biomedical Research Centre by Dr Gordon Moran.

 

Who can take part?

We are inviting all porentially suitable people to take part.

  • Aged 18 years or older
  • Have a diagnosis of Crohn’s Disease for at least 6 months
  • Your Crohn’s disease is under control
  • Currently taking an oral mesalazine for at least 6 months
  • Willing to stop taking your oral mesalazine